Над альбомом работал американский композитор Грег Эдмонсон (Uncharted: The Nathan Drake Collection, Uncharted: Drake's Fortune, Uncharted 3: Drake’s Deception), а его релиз состоялся 9 января 2007 года. На саундтрек попало 25 композиций общей длительностью более часа. Подборка является компиляцией оригинальной музыки. Выпуском пластинки занимался лейбл Fox Music.
CD 1
| 1 | Firefly - Main ThemeJoss Whedon | 00:52 |  |
| 2 | Big Bar FightGreg Edmonson | 01:56 | |
| 3 | Heart of Gold MontageGreg Edmonson | 02:10 | |
| 4 | Whitefall / BookGreg Edmonson | 02:20 | |
| 5 | Early Takes the SerenityGreg Edmonson | 02:36 | |
| 6 | The FuneralGreg Edmonson | 02:36 | |
| 7 | River's Perception / SaffronGreg Edmonson | 02:14 | |
| 8 | Mal Fights Niska / Back HomeGreg Edmonson | 01:54 | |
| 9 | River Tricks EarlyGreg Edmonson | 03:30 | |
| 10 | River Understands SimonGreg Edmonson | 02:04 | |
| 11 | Leaving / Caper /SpaceballGreg Edmonson | 02:39 | |
| 12 | River's Afraid / Niska /TortureGreg Edmonson | 03:21 | |
| 13 | In My Bunk / Jayne's Stature / BoomGreg Edmonson | 02:28 | |
| 14 | Inara's SuiteGreg Edmonson | 03:29 | |
| 15 | Out of Gas / Empty DerelictGreg Edmonson | 01:50 | |
| 16 | Book's Hair / Ready for BattleGreg Edmonson | 01:59 | |
| 17 | Tears /River's EyesGreg Edmonson | 01:59 | |
| 18 | Cows / New Dress /My CrewGreg Edmonson | 02:11 | |
| 19 | Boarding the Serenity / DerelictGreg Edmonson | 02:02 | |
| 20 | Burgess Kills / Captain & ShipGreg Edmonson & Alan Steinberger | 03:26 | |
| 21 | Saved /Isn't Home? / ReaversGreg Edmonson | 02:55 | |
| 22 | Reavers Chase SerenityGreg Edmonson | 03:22 | |
| 23 | River's DanceGreg Edmonson | 01:50 | |
| 24 | Inside the Tam HouseGreg Edmonson & Alan Steinberger | 02:22 | |
| 25 | Dying Ship / Naked MalGreg Edmonson & Alan Steinberger | 02:10 | |
